![]() Standard approach for detecting variants. If cost was not an issue, whole genome sequencing ( WGS) would be the Typically used in characterizing 3D interactions of DNAĭNA or RNA sequencing of individual cells, captures granularity at an individual cell level rather than a mixture of cells, can be coding or non-coding with lower coverage The region can be coding or non-coding and is typically focused, high-depth sequencing for validating variantsĬharacterizes any sequence the genomic locations where a protein interacts with DNA, both coding and non-codingĬharacterizes any sequence where DNA does not interact with proteins or is "open", both coding and non-codingĬharacterizes the genomic locations where chromosomes come in close contact with each other. Common Sequence Applications Area of the genomeĬharacterizes the entire genome reading sequences from DNAĬharacterizes the exonic, or coding, regions of the genome reading sequences from DNAĬharacterizes the exonic regions that are actively expressed in the cell reading sequences from RNAĬharacterizes a chosen region from DNA, can be a coding or non-coding region. ![]() This section discusses what scientists weigh whenĭeciding which pieces of the genome/exome/transcriptome needs sequencing. Often, the type of sequencing ordered is a trade-off between cost and Of known mutations, while population studies focus on the discovery of new For example, clinical sequencing seeks the time-sensitive detection Of the research, cost and practical limits determine which types of sequencingĪre chosen. Each sequencing type is best analyzed by a differentĬomputational method and is interpreted in a different way. Sequencing is a laboratory technique that identifies and determines the order ofīases in a DNA molecule.
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